Novel non-nucleoside inhibitors of human immunodeficiency virus type 1 reverse transcriptase. 6. 2-Indol-3-yl- and 2-azaindol-3-yl-dipyridodiazepinones

T A Kelly; D W McNeil; J M Rose; E David; C K Shih; P M Grob

doi:10.1021/jm960837y

Novel non-nucleoside inhibitors of human immunodeficiency virus type 1 reverse transcriptase. 6. 2-Indol-3-yl- and 2-azaindol-3-yl-dipyridodiazepinones

J Med Chem. 1997 Jul 18;40(15):2430-3. doi: 10.1021/jm960837y.

Authors

T A Kelly¹, D W McNeil, J M Rose, E David, C K Shih, P M Grob

Affiliation

¹ Research and Development Center, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, Connecticut 06877, USA.

PMID: 9240358
DOI: 10.1021/jm960837y

Abstract

Modification of the non-nucleoside inhibitor of HIV-1 reverse transcriptase nevirapine (Viramune) by incorporation of a 2-indolyl substituent confers activity against several mutant forms of the enzyme.

MeSH terms

Anti-HIV Agents / chemistry
Anti-HIV Agents / pharmacology
Cell Line
HIV Reverse Transcriptase / antagonists & inhibitors*
Humans
Magnetic Resonance Spectroscopy
Nevirapine
Pyridines / chemistry
Pyridines / pharmacology*
Reverse Transcriptase Inhibitors / chemistry
Reverse Transcriptase Inhibitors / pharmacology*

Substances

Anti-HIV Agents
Pyridines
Reverse Transcriptase Inhibitors
Nevirapine
HIV Reverse Transcriptase